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Matsue is located in southwest Japan, in the north of Shimane Prefecture. Shimane is part of the Chugoku Region, along with four other prefectures (Tottori, Okayama, Hiroshima, and Yamaguchi).

The Chugoku Region is commonly subdivided into the San-yo Region (south side) along the Seto Inland Sea coast, and the San-in Region (north side) along the Sea of Japan coast, of which Matsue is the largest city.